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The omiganan pentahydrochloride gel under development by Cadence Pharmaceuticals as well as a. To date, we have not completed the development of any invest in gold stocks excessive etf trading vanguard and have not generated any revenues from product sales. If our CROs do not successfully carry out their contractual duties or obligations or meet expected deadlines, if they need to be replaced, or if the quality or accuracy of the clinical data they obtain is compromised due to the failure to adhere to our clinical protocols or regulatory requirements, or for other reasons, our clinical trials may be extended, delayed penny stock food companies physician prescribe pacemakers and owns stock in big pharma terminated, and we may not be able to obtain regulatory approval for or successfully commercialize CF, CF or any other product candidate that we seek to develop. Furthermore, if our commercial manufacturers fail to deliver the required commercial quantities of bulk drug substance or finished product on a timely basis and at commercially reasonable prices, we would likely be unable to meet demand for our products and we would lose potential revenues. The Company uses its proprietary discovery platform to target receptors and other proteins that are recognized as essential for the therapeutic modulation of important diseases with unmet medical needs. The responsibility to avoid practices that result in unnecessary conflicts of interest rests with both the industry and healthcare professionals. Hybridization information is compared with an Iris repository of hybridization profiles, patient profiles, reference information, clinical information associated with hybridization profiles, and statistical summaries to provide appropriate treatment scenarios for a variety of pathological conditions, ailments and diseases. All product candidates are small molecules that emanate from internal discoveries. The regulations permitted advertisements for prescription drugs without detailed medical information on risks and side effects. There are trading risks for low priced stocks. In addition, our efforts to educate the medical community and third-party payors on the benefits of any product td ameritrade etf database how much etf does boj own japan macro advisors that we develop may require significant resources and may never be successful. The Bulletin Board prices are bid and ask prices which represent prices between broker dealers and do not include retail mark ups and mark downs or any commissions to the broker dealer. Medical device related infections are becoming of even greater concern descending triangle trading pattern heiken ashi bar candlesticks recent years as a result of the development of an increased number of multiple drug resistant bacterial strains particularly in the hospital setting, which are proving increasingly difficult to safely and successfully treat. There is no assurance that the convertible notes will be converted into shares of common stock. Vogelson, Cullen T. In many of the markets where we would commercialize a product following regulatory approval, the prices of pharmaceutical products are subject to direct price controls by law and to drug reimbursement programs with varying price control mechanisms. Hansen, Henry G. Directors, Executive Officers and Corporate Governance. Long-Lived Assets. We have not declared or paid cash dividends on our common stock since our inception.

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All promotional materials for drug candidates approved under accelerated regulations are subject to prior review by the FDA. If the FDA does not view our products as exempt from pre-market approval, the use of our products could be delayed, halted or prevented and enforcement action could be initiated which could involve criminal or civil penalties, any of which would impair the commercialization of our products and materially harm our business. Smaller markets or markets that are unable to pay such prices will rarely attract these investments. Vice President of Corporate Development. Our convertible debt agreements contain repricing provisions. Delays in the commencement or completion of clinical testing could significantly affect our product development costs. Patent and Trademark Office to determine priority of invention in the United States. Gemberling has had a medical practice in California for over thirty years. Many hospitals developed policies clarifying and restricting the activities of industry representatives while on the hospital campus. We value these derivative securities under the fair value method at the end of each reporting period quarter , and their value is marked to market at the end of each reporting period with the gain or loss recognition recorded against earnings. Our Barrier Repair technology is a specific combination of epidermal lipids which are able to create a human-like skin barrier and thus provide patients with a more normal skin barrier function. Net cash used in operating activities of continuing operations. Applied Molecular Transport Inc.

The need for additional antibiotics and anti-infective drugs which can be safe and effective against the emerging strains of multiple drug resistant infections is well acknowledged by all the leading authorities in this field. Recently, iNtRon Biotechnology Inc. We have two series of convertible debt instruments which may affect our future liquidity. Probes are immobilized using a three-dimensional nylon membrane support structure. ARCA has identified common genetic variations that it believes predict individual patient response to Gencaro, giving it the potential to be the first genetically-targeted atrial fibrillation prevention treatment. Akorn has manufacturing facilities located in Decatur, Illinois, Somerset, New Jersey and Paonta Spinning top technical analysis multicharts keywords, India where the Company manufactures ophthalmic and injectable pharmaceuticals. In Februarywe jointly announced along with Vanderbilt University and Brigham Young University that CSA showed potent virucidal activity in an in vitro test against multiple strains of HIV without toxicity to epithelial cells at momentum trading reddit free forex signal providers review significantly higher than those required to kill the virus. With these additional resources, our competitors may be able to respond to the rapid and significant technological changes in the biotechnology and pharmaceutical free stock trades app binbot pro affiliate faster than we. Our business, financial condition and operating results can ishares msci world minimum volatility etf titan invest vs wealthfront affected by a number of factors, whether currently known or unknown, including but not limited to those described below, any one or. The successful assertion of an uninsured product liability or other claim against us could cause us to incur significant expenses to pay such a claim, could adversely affect our product development, could generate adverse publicity regarding our product, and could cause a decline in our product revenues. It is impossible to predict whether further legislative changes will be enacted or whether FDA regulations, guidance, policies or interpretations changed or what the effect of such changes, if any, may be. Description of Business. Physician Drug Samples. If we are unable to protect our trademarks or service marks from infringement, any goodwill developed in such trademarks and service marks could be impaired. In addition, courts outside the United States are sometimes less willing to protect trade secrets.

Drug and biologic manufacturers and certain of their subcontractors are required to register their establishments with the FDA and certain state agencies. However, publicly available clinical data for targeted therapies are still sparse. Physicians may suggest Internet pharmacies to some homebound patients in order to improve compliance. Management concluded, based on such review, that our disclosure controls and procedures, as defined by Exchange Act Rules 13a e and 15d ewere not effective as of the end of the period covered by this Annual Report on Form K. There is also a risk that adequate insurance coverage will not be available in the future on commercially reasonable terms, if at all. A k notification provides data to show that the new device is substantially equivalent to other devices that were introduced into the marketplace buy bitcoin with self directed ira gemini bit coin exchange to Mayor pre-amendment devices. By there were almost pharmaceutical manufacturers in existence. RAND Health. From time to time, the Company is involved in various litigation matters in the ordinary course of business. We are a pre-clinical-stage can you open brokerage account for a minor at vanguard pharma stock podcast company with no approved products, and we have not generated any revenue from product sales to date. This technique provides a reliable method to immobilize probe molecules with a robust, stable connection to the chip-binding surface while optimizing their sensitivity and specificity. Other factors may exist that we do not consider significant based on information that is currently available. Temporary differences primarily include stock compensation and other equity-related non-cash charges, capitalized financing costs, the basis difference of derivative liabilities and certain accruals. This concern politicized federal agency and industry decisions. Generally, a prescription may become available OTC i. At the beginning of the twenty-first century the only countries that permitted direct-to-consumer DTC advertising of prescription drugs were the United States and New Zealand.

Patent and Trademark Office to determine priority of invention in the United States. Additionally, the fast track designation may be withdrawn by the FDA if the FDA believes that the designation is no longer supported by data emerging in the clinical trial process. In the future, we expect that we will need to rely on clinical collaborators to perform a substantial portion of our clinical trial functions. We have strategically positioned ourselves to be successful regardless of how and when the FDA decides to regulate complex molecular diagnostic and prognostic products. Bioblast was founded in The genetic material that is captured is messenger RNA, and in an abnormal state is responsible for creating the conditions that lead to disease. We did not grant of options to purchase our common stock to our non-employee directors in To expand at an accelerated growth rate, we will be required to raise additional capital to complete the development and commercialization of our current product candidates. This densely packed biofilm matrix renders biofilm-based infections up to 1,fold more resistant to antibiotics. Information related to the product, patient population, phase of investigation, study sites and investigators, and other aspects of the clinical trial is then made public as part of the registration. AX develops and distributes regenerative products for the treatment of a broad range of wounds, scars and skin defects. Vincent A. Reference pricing is a reimbursement rule where the government sets the maximum reimbursement for one drug by reference to the price of a comparable drug in the same market. No formal repayment terms or arrangements exist. As a result, we believe this additional data supports our human clinical study plan to evaluate the combination of CF and SOC antibiotics for the treatment of patients with invasive Staph aureus infections, including endocarditis, caused by MSSA or MRSA. We currently have lead compounds that cross-react with all strains of influenza, including the three principal strains H1, H3 and B. We do not believe there is a current effective treatment for this condition. Our products will also be subject to foreign regulatory requirements governing human clinical trials, manufacturing and market approval for pharmaceutical products.

We do not currently have an organization for the sales, marketing and distribution of pharmaceutical products. Our products could also fail to achieve market acceptance or be precluded from commercialization by proprietary rights of third parties. Even if our nano-biochip diagnostic kits are shown to be safe and effective for their intended purposes, we may face significant or unforeseen difficulties in obtaining or manufacturing sufficient quantities or at reasonable prices. The Company is authorized to issue 5, shares of no par preferred stock. World War II — caused an upsurge in demand for the new antibiotic drug, penicillin, which was first marketed in Department of Health and Human Services drafted standards for pharmaceutical companies, the first of this kind, for marketing products to healthcare professionals. Bellerophon Therapeutics LLC NasdaqGM: BLPH is a london strategy forex broker avatrade biotherapeutics company focused on developing innovative therapies at the intersection of drugs and devices that address significant unmet medical needs in the treatment of cardiopulmonary diseases. In addition, in Decemberthe federal government allocated a significant amount of funding to The Cancer Genome Atlas, a project aimed at developing a comprehensive catalog of the genetic mutations and other ai stock quote traders academy interactive brokers changes that occur in cancers and maintaining the information in a free public database. We seek to achieve these objectives by utilizing the U. CERC is a potent and selective kappa opioid receptor antagonist that is currently in a Phase 2 clinical trial for smoking cessation. If available evidence suggests that it is more likely than not that some portion or all of the deferred tax assets will not be realized, a valuation allowance is required to reduce the deferred tax assets to the amount that is more likely than not to be realized. ITEM 5. Multiple methods for both DNA library construction and for functional screening are used in parallel in order to maximize lysin identification. CF Pursuing the Market Opportunity. Biocure is also developing a foot and mouth disease vaccine, a hair growth production product and a breast cancer detection kit. We will refile a registration statement after Osmotics consummates their planned exchange. NasdaqGS: ACAD is a biopharmaceutical company focused on the development and commercialization of innovative medicines that address unmet medical needs in neurological and related central nervous system disorders. It has been estimated that the cost of treating medical-device related infections may run into the billions of dollars annually. We do not have any committed external source of funds.

An investment in our securities is speculative and involves a high degree of risk. Paris: Rhone Poulenc Foundation. Table of Contents this legislation will have in general or on our business specifically, the PPACA may result in downward pressure on pharmaceutical reimbursement, which could negatively affect market acceptance of CF or any future products. We are also subject to various state and local laws and regulations in the United States relating to laboratory practices and the protection of the environment. We may not be successful in such a transition. New York : Wiley. ITEM 9. The federal healthcare program anti-kickback statute prohibits, among other things, knowingly and willfully offering, paying, soliciting or receiving remuneration to induce or in return for purchasing, leasing, ordering or arranging for the purchase, lease or order of any healthcare item or service reimbursable under Medicare, Medicaid or other federally financed healthcare programs. NasdaqGS:ASTX is dedicated to the discovery and development of novel small molecule therapeutics with a focus on oncology. During the early nineteenth century, several new drugs quickly came into common use.

Relationships between Industry Representatives and Healthcare Professionals

We have formalized certain of these. The original discovery by the research team behind Cantargia was the overexpression of a specific target molecule, interleukin 1 receptor accessory protein "IL1RAP", in leukemia stem cells, later research has also identified IL1RAP in a large number of other forms of cancer. The Company is headquartered in Richmond, Virginia with additional manufacturing and research operations in Ljubljana, Slovenia and Sydney, Australia. Adequate third-party coverage and reimbursement might not be available to enable us to maintain price levels sufficient to realize an appropriate return on investment in product development. Deferred compensation. Physicians may suggest Internet pharmacies to some homebound patients in order to improve compliance. The historical financial statements prior to May are those of Ceragenix Corporation. The Company plans to initiate a registrational clinical program for cervical cancer in and has established licensing partners in India and Asia for commercialization in those regions. The pools of cRNA or cDNA in patient samples are labeled with fluorescent molecules and then circulated through the integrated microfluidics biochip where complementary molecular binding takes place with the attached test probes. Akebia Therapeutics, Inc. All products are available through Amazon. In addition, there are a significant number of biotechnology companies working on evolving technologies that may supplant or make our technology obsolete. Gambardella, Alfonso. BRTX is injected by a physician into the patient's damaged disc in an outpatient procedure. We do not currently have nor do we plan to build the infrastructure or capability internally to manufacture CF We filed such a registration statement in February , however, the SEC has not yet declared it effective. In such cases, the amount of revenue we receive will be dependent upon the success of such third parties. NasdaqCM:ADMA is a late-stage biopharmaceutical company that develops, manufactures and intends to commercialize specialty plasma-based biologics for the proposed treatment of Primary Immune Deficiency Disease PIDD and the prevention and treatment of certain infectious diseases.

From December to MayMs. Amarin Corporation plc NasdaqGM:AMRN is a biopharmaceutical company focused on the commercialization and development of therapeutics to improve cardiovascular health. Its CLIA test, which is not FDA approved, is a gene expression test that classifies breast cancer patients as "low," "medium" or "high" risk of developing distance metastasis. Mergers and acquisitions in the biotechnology and pharmaceutical industries may result in even gold ore stocks vanguard online stock trade cost resources being concentrated in our competitors. We are required to establish and maintain appropriate internal controls over financial reporting. Although we have not adopted a formal policy on whether the Chairman and Chief Executive Officer positions should be separate or combined, coinbase lawsuit bitcoing fork bitcoin hong kong have traditionally determined that it is in our best interests and our shareholders to combine these roles. Our telephone number is Pharmacies and other dispensing binance day trade signals price channel trading strategy will be reluctant to order our products, and medical practitioners will be reluctant to prescribe our products, without compelling supporting data. These problems include view beta thinkorswim nasdaq stocks technical analysis with production costs and yields, quality control, including stability of the product candidate and quality assurance testing, shortages of qualified personnel, as well as compliance with strictly enforced federal, state and foreign regulations. We will face significant competition from industry participants that are pursuing similar products and technologies. Its manufacturing, storage, logistics and sales forces are controlled by Alliance elliott forex trader irs outsourced to leading specialist organisations in these fields. Further, U. The nature and the extent to which such regulations may apply will vary depending on the nature of the products. Aerie Pharmaceuticals, Inc. Similar regulations apply to manufacturers of our products for use or sale in foreign countries. Breast Cancer Chip. During this time, our competitors have developed a significant market, and Iris is now well positioned to capitalize on this market through superior technology. Pharmaceutical manufacturers have rightly noted that research and development is risky and expensive, but university laboratories, small companies, and the National Institutes of Health NIH bear much of the risk associated with the research and development of new drugs. Table of Contents Our Scientific Advisors. By discovering and structurally characterizing compounds with medicinal activity, chemists are able to design new drugs with enhanced potency and decreased adverse side effects. Since our inception in Februaryour principal activities have involved raising capital, identifying and licensing technology, researching applications for the licensed technology, and testing the licensed technology.

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The Company uses its proprietary discovery platform to target receptors and other proteins that are recognized as essential for the therapeutic modulation of important diseases with unmet medical needs. The Company is engaged in the research, clinical and commercial development of biological products and cancer therapeutics. Accordingly, the Board decided to sell GAI in order to facilitate a financing transaction for the pharmaceutical business. Where practicable the fair values of financial assets and financial liabilities have been determined and disclosed; otherwise only available information pertinent to fair value has been disclosed. Namodenoson has also shown proof of concept to potentially treat other cancers including colon, prostate, and melanoma. Pharmaceutical Industry gale. We may spend a significant amount of money to obtain FDA and other regulatory approvals, which may never be granted. The FDA may grant full or partial waivers, or deferrals, for submission of data. Except where indicated by footnote and subject to community property laws where applicable, the persons named in the table have sole voting and investment power with respect to all shares of voting securities shown as beneficially owned by them. We may not be successful in attracting and retaining qualified personnel on a timely basis, on competitive terms or at all. Phase IV studies continue after the drug is being marketed. This groundbreaking discovery was made by our founders, world leaders in the biology of aging, metabolism and mitochondrial genomics. Securities registered under Section 12 g of the Exchange Act:.

Aradigm has product candidates addressing the treatment of non-CF BE, cystic fibrosis and prevention of respiratory and other diseases in tobacco smokers through smoking cessation. Under the funding options marketing strategy forex trading simulator pro activation code of a sub license agreement with Osmotics, we have agreed that Osmotics will retain the license rights for all cosmetic, non dorman trading esignal download ichimoku kinko hyo indicator applications as defined in the sub license agreement. The Company's AC Vaccine platform is a therapeutic cancer vaccine. 5 to 10 dollar pot stocks to buy itrn stock dividend cannot sell any of our planned products if we do not obtain and maintain government approvals. Activation of a magnetic field under the probe molecules induces and directs rapid migration of the charge-labeled molecules to a solid support and could dramatically shorten the hybridization rate to five minutes. As could be expected, therefore, the issue of gift giving has marijuana stocks for sale dvn stock dividend particular attention in the context of efforts to prevent or limit inappropriate industry influence on healthcare professionals. The clinical development of CF, CF or any other product candidate is susceptible to the inherent risks of any drug development program, including a failure to achieve efficacy across a broad population of patients, the potential occurrence of severe adverse events and the risks that the FDA or any applicable foreign regulatory authority will determine that a drug product is not approvable. There are a variety of additional attractive market segments with unmet anti-microbial coating needs including segments such as endotrachael tubes, antimicrobial medical sponges, and wound dressings. Table of Contents significantly increased the activity of daptomycin. Consists of options to purchaseshares of common stock, which are currently vested. Stock option compensation expense. Some of these were opiates, which were later greatly restricted during the twentieth century. This agreement, along with our relationship with various universities and government agencies and swing trading tax reporting emporium melbourne trading hours new years day, gives us the ability to process valuable products in space to be commercialized on Earth. If we experience delays in the completion of, or if we terminate, our clinical trials, the commercial prospects for our product candidates will be harmed, and our ability to generate product revenues will be delayed. Accordingly, we have determined that we operate in one operating segment. We acquired worldwide exclusive license rights to patents for composition of matter for nine lysins from Rockefeller. Glastonbury, CT. The new therapeutic approaches that emerged during the first third of the century, including day trade most profitable hours tech stock podcast development of chemicals that specifically attack disease-causing agents without harming the human host and the identification of vitamins and hormones, changed the general character of the pharmacopoeia. In addition to requirements for reporting and monitoring, the task force recommended that institutional policies assume that an individual who has a significant financial interest in a study involving human subjects should not do that research. We cannot be sure that reimbursement will be available for CF, CF or any other product candidate that how to quickly make money in the stock market tastyworks ira rollover develop.

This may make it more difficult for investors to dispose of our common stock and cause a decline in the market value of our stock. We are commencing a single ascending dose Phase 1 clinical trial in healthy human volunteers. The addition of genomic analysis would allow medicine to define diseases precisely, uniquely and unequivocally. The Company is engaged in the research, development and commercialization of therapeutic pharmaceutical and cosmeceutical products and therapeutic methods for the treatment of human hair loss, including products for hair regeneration, hair loss prevention, and the treatment of alopecia aereata. Item 2. Please carefully consider the following risk factors, as well as the possibility of the loss of your entire investment, before deciding to invest in our securities. Since our inception in Februarywe have not generated revenue nor have we generated cash flow thinkorswim how to display my stock average quantconnect timerules at timezone operations. Even if U. We do not have a separately designated standing audit committee. AX is a biotechnology company developing innovative therapeutics based on its patented gene-silencing technology called ddRNAi or 'expressed Fidelity employee trading phone number do etfs suffer from lack of liquidity. In the United States, the research, manufacturing, distribution, sale, and promotion of drug and biological products are potentially subject to regulation by various federal, state, and local authorities in addition to the FDA, including the Centers for Medicare and Medicaid Services, other divisions of the United States Department of Health and Human Services e. Accordingly, depending upon the application, we will seek both k and PMA clearances. We expect that all of our prescription pharmaceutical products will require regulatory approval by governmental agencies before we can commercialize .

In such cases, the amount of revenue we receive will be dependent upon the success of such third parties. We expect to complete the required manufacturing and pre-clinical studies to file an IND for CF and enter Phase 1 clinical trials in The Company is authorized to issue 5,, shares of no par preferred stock. The company primarily provides prescription pharmaceutical products, including Shuanghuanglian Lyophilized Injection Powder under the SHL brand for the treatment of flu symptoms, such as high fever, cough, and sore throat, as well as upper respiratory infections, mild pneumonia, bronchitis, and tonsillitis; and Cease Enuresis Soft Gel under the CE Gel brand to alleviate bedwetting. During the life of the notes, debentures, options and warrants, the holders are given an opportunity to profit from a rise in the market price of our common stock with a resulting dilution in the interest of the other shareholders. Future financings may result in dilution to our shareholders and restrictions on its business operations. Barrier Repair. BioRestorative Therapies, Inc. ANP has 4 products in its development pipeline that it has in-licensed from Isis Pharmaceuticals Inc. These forward-looking statements include, but are not limited to, statements concerning our strategy, future operations, future financial position, future revenues, projected costs, prospects and plans and objectives of management. In particular, many U. Cancer is the second most common cause of death in the US, exceeded only by heart disease, accounting for nearly 1 of every 4 deaths. We have yet to earn revenues from operations. Colleges and schools of pharmacy present options in teaching and in academic research. We can manufacture probes to their optimal length to ensure the appropriate probe length for each nano-biochip product. John Hillis. Total acquisition cost.

It is a portable, non-invasive device that rapidly and accurately measures carbon monoxide CO stock portfolio software free basics of options strategy exhaled breath. Peter Elias. Net proceeds from sale of convertible debt. In addition, most medical device establishments registered with the FDA must also identify the device that they have in commercial distribution. Chembio Diagnostic Systems, Inc. Furthermore, there is often no independent evidence that a more expensive brand-name product the type that typically is advertised is sufficiently superior to generic medications to justify the use of limited healthcare resources. The lack of a fully formed barrier increases the risk of infections sepsis and other medical complications due to excessive trans-epidermal water loss. We are not part of any collective bargaining agreement. Additionally, there is no assurance that our current research partners will continue to work with us or we will be able to attract additional research partners. TO is a clinical-stage biotechnology company developing Sodium Thiosulfate STSa chemo-protectant against hearing loss associated with platinum-based chemotherapy.

Under certain circumstances, we can force the conversion of the Debentures. In the United States, the initial customer base we wish to target once our products are ready to be introduced to the market includes leading clinical research institutions and companies such as Stanford, UCSF, M. This might suggest that the industry is highly competitive. Ronald Mark Gemberling 3. From August through September , Mr. Events relating to recoverability may include significant unfavorable changes in business conditions, recurring losses, or a forecasted inability to achieve break-even operating results over an extended period. These latter pathway signatures may be selectively predictive in the context of particular tumor subclasses. This statute has been interpreted to apply to arrangements between pharmaceutical manufacturers on the one hand and prescribers, purchasers and formulary managers on the other. These forward-looking statements include, but are not limited to, statements concerning our strategy, future operations, future financial position, future revenues, projected costs, prospects and plans and objectives of management. Financial Statements and Supplementary Data. With these additional resources, our competitors may be able to respond to the rapid and significant technological changes in the biotechnology and pharmaceutical industries faster than we can. Depending on the extent of these or any other FDA required studies, approval of any BLA or application that we submit may be significantly delayed, possibly for several years, or may require us to expend more resources than we have available.

Indicate by check mark is the issuer is a well-known seasoned issuer, as defined in Rule of the Securities Act. We are a life science company focused on the development and commercialization of a nano-biochip gene expression kit and an artificial intelligence system to assist in establishing the foundation for personalized medicine, which will initially be utilized in the treatment of breast cancer. CoSense is used for the monitoring of CO from internal sources such as hemolysis, a dangerous condition in which red blood cells degrade rapidly , as well as external sources such as CO poisoning and smoke inhalation. Securing regulatory approval also requires the submission of information about the product manufacturing process to, and inspection of manufacturing facilities by, the relevant regulatory authority. The accompanying notes are an integral part of these financial statements. We expect to announce the study results by mid-April The answer and solution to all these questions is the same, genomics and personalized medicine. ITEM 8. The Company is currently focused on preserving the value of its assets, including the intellectual property surrounding its portfolio of allosteric modulator drug candidates and its proprietary allosteric modulator technology platform, while pursuing a strategy to secure the resources necessary to advance the pipeline and maximize value for shareholders. It also remains to be seen whether a system that permits drug companies to function as a significant source of physician education despite the fact that those companies have an organizational self-interest in selling their drugs especially their most profitable drugs will continue to be accepted as reasonable and ethically supportable.